From 8ecf2d11982e7ff2563534246ae19a088e445868 Mon Sep 17 00:00:00 2001
From: mite-bot <zdoucmm@gmail.com>
Date: Tue, 14 Jul 2026 14:11:15 +0200
Subject: [PATCH 1/2] Add submission UUID file

---
 .../06340ca6-7f7d-11f1-9115-dd113f401ed3.json | 44 +++++++++++++++++++
 1 file changed, 44 insertions(+)
 create mode 100644 mite_data/data/06340ca6-7f7d-11f1-9115-dd113f401ed3.json

diff --git a/mite_data/data/06340ca6-7f7d-11f1-9115-dd113f401ed3.json b/mite_data/data/06340ca6-7f7d-11f1-9115-dd113f401ed3.json
new file mode 100644
index 00000000..a0c77a85
--- /dev/null
+++ b/mite_data/data/06340ca6-7f7d-11f1-9115-dd113f401ed3.json
@@ -0,0 +1,44 @@
+{
+    "accession": "MITE9999999",
+    "status": "pending",
+    "changelog": [
+        {
+            "version": "1",
+            "date": "2026-07-14",
+            "contributors": [
+                "0009-0000-8651-1669"
+            ],
+            "reviewers": [
+                "BBBBBBBBBBBBBBBBBBBBBBBB"
+            ],
+            "comment": "New entry."
+        }
+    ],
+    "enzyme": {
+        "name": "CmlS",
+        "databaseIds": {
+            "uniprot": "F2RB87",
+            "genpept": ""
+        },
+        "references": [
+            "doi:"
+        ]
+    },
+    "reactions": [
+        {
+            "evidence": {
+                "evidenceCode": [],
+                "references": [
+                    "doi:"
+                ]
+            },
+            "reactions": [
+                {
+                    "products": [
+                        ""
+                    ]
+                }
+            ]
+        }
+    ]
+}
\ No newline at end of file

From 00dd39c81a96be96da24ed71e98c2f091d23488f Mon Sep 17 00:00:00 2001
From: mite-bot <zdoucmm@gmail.com>
Date: Tue, 14 Jul 2026 15:09:39 +0200
Subject: [PATCH 2/2] Update submission

---
 .../06340ca6-7f7d-11f1-9115-dd113f401ed3.json | 57 ++++++++++++++-----
 1 file changed, 44 insertions(+), 13 deletions(-)

diff --git a/mite_data/data/06340ca6-7f7d-11f1-9115-dd113f401ed3.json b/mite_data/data/06340ca6-7f7d-11f1-9115-dd113f401ed3.json
index a0c77a85..be798eda 100644
--- a/mite_data/data/06340ca6-7f7d-11f1-9115-dd113f401ed3.json
+++ b/mite_data/data/06340ca6-7f7d-11f1-9115-dd113f401ed3.json
@@ -1,6 +1,7 @@
 {
     "accession": "MITE9999999",
     "status": "pending",
+    "comment": "Dichlorination of CoA-S-acetoacetyl in the chloramphenicol pathway. No specific flavin reductase was identified in this genecluster. Additional GenPept: AAK08979.2",
     "changelog": [
         {
             "version": "1",
@@ -16,29 +17,59 @@
     ],
     "enzyme": {
         "name": "CmlS",
+        "description": "Flavin-dependent halogenase",
+        "references": [
+            "doi:10.1016/j.jmb.2010.01.020"
+        ],
+        "auxiliaryEnzymes": [
+            {
+                "name": "CmlK",
+                "description": "Long-chain fatty acid CoA ligase",
+                "databaseIds": {
+                    "uniprot": "F2RB86",
+                    "genpept": "CCA54214.1"
+                }
+            }
+        ],
         "databaseIds": {
             "uniprot": "F2RB87",
-            "genpept": ""
+            "genpept": "CCA54215.1",
+            "mibig": "BGC0000893"
         },
-        "references": [
-            "doi:"
-        ]
+        "cofactors": {
+            "organic": [
+                "Coenzyme A",
+                "FAD",
+                "NAD",
+                "NADP"
+            ]
+        }
     },
     "reactions": [
         {
-            "evidence": {
-                "evidenceCode": [],
-                "references": [
-                    "doi:"
-                ]
-            },
+            "tailoring": [
+                "Halogenation"
+            ],
+            "description": "Dichlorination of acetoacetyl-CoA, catalyzed through E44 residue, which removes structurally protons reducing the acidity in the pocket.",
+            "reactionSMARTS": "[#6]-[#6](-[#6:4]-[#6:5](-[#16:7]-[*])=[#8:6])=[#8]>>Cl-[#6:4](-[Cl])-[#6:5](-[#16:7]-[*])=[#8:6]",
             "reactions": [
                 {
+                    "substrate": "*SC(=O)CC(C)=O",
                     "products": [
-                        ""
-                    ]
+                        "*SC(=O)C(Cl)Cl"
+                    ],
+                    "isIntermediate": true
                 }
-            ]
+            ],
+            "evidence": {
+                "evidenceCode": [
+                    "Knock-out studies"
+                ],
+                "references": [
+                    "doi:10.1016/j.jmb.2010.01.020",
+                    "doi:10.1099/mic.0.26319-0"
+                ]
+            }
         }
     ]
 }
\ No newline at end of file