Add plain-language depression trial summary (#464)#477
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yehudalevy-collab wants to merge 2 commits into
Draft
Add plain-language depression trial summary (#464)#477yehudalevy-collab wants to merge 2 commits into
yehudalevy-collab wants to merge 2 commits into
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Address review feedback on OpenwaterHealth#464: - The half-of-cohort medication note said 'for anxiety or depression', but Table 1 lists non-antidepressant medications too; the paper's own wording is neutral ('current psychiatric medication use'). - Add the C-SSRS suicidality-monitoring outcome (no imminent-risk ideation; one transient post-week-3 increase the authors attributed to an unrelated personal event), which the safety paragraph had omitted. Co-Authored-By: Claude Opus 4.8 <noreply@anthropic.com>
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Summary
Closes #464.
Adds an 823-word plain-language summary of the University of Arizona Open-LIFU depression trial for prospective participants, IRB members, and other non-specialist readers.
The issue refers to a wiki "Clinical Resources" section. The public wiki does not currently expose that structure, while the maintainer guidance and repository-based delivery used for #459 / #475 place the Markdown in this repository. I followed that live precedent with a root-level file and am happy to relocate it if maintainers prefer another path.
Clinical-framing notes
The paper is internally inconsistent about why two participants withdrew: the abstract says time constraints, while the Results and Discussion say lack of symptom improvement. The summary reports both accounts and retains the point on which the paper is consistent: withdrawal was not attributed to an adverse event.
The paper does not print exact group-average BDI-II values for weeks 1 and 3. The summary therefore reports the exact baseline mean and modeled change, describes the visible trajectory in Figure 3, and does not estimate follow-up means from the chart.
Clinician review remains required before merge, as specified in #464. After the English clinical wording is approved, I would also be glad to prepare a Spanish version if that would be useful.
Test plan
pre-commitondepression_trial_summary.md(all applicable hooks pass, including Prettier and codespell)