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Contributor submission AryC #784

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mite-bot Jul 13, 2026
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mite-bot Jul 13, 2026
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68 changes: 68 additions & 0 deletions mite_data/data/b34629ba-7edd-11f1-9115-dd113f401ed3.json
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{
"accession": "MITE9999999",
"status": "pending",
"comment": "AryC is a Cytochrome P450 monooxygenase responsible for the C-C biaryl bond formation in arylomycins.",
"changelog": [
{
"version": "1",
"date": "2026-07-13",
"contributors": [
"0009-0008-8086-5325"
],
"reviewers": [
"BBBBBBBBBBBBBBBBBBBBBBBB"
],
"comment": "New entry."
}
],
"enzyme": {
"name": "AryC",
"description": "Cytochrome P450",
"references": [
"doi:10.1021/ja2040877",
"doi:10.1002/chem.202103389"
],
"databaseIds": {
"uniprot": "UPI0001AEDB4C",
"genpept": "EWS95123.1",
"mibig": "BGC0000306"
},
"cofactors": {
"organic": [
"Heme"
],
"inorganic": [
"Fe"
]
}
},
"reactions": [
{
"tailoring": [
"Biaryl bond formation"
],
"description": "AryC catalyzes C-C biaryl bond formation resulting in Arylomycin A2.",
"reactionSMARTS": "[#6:1]-[#6:2]-[#6:3]-[#6:4]-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]-[#6:13]-[#6:14]-[#6:15]-[#6:16](-[#7:18](-[#6:20](-[#6:23](-[#7:25]-[#6:26](-[#6:28](-[#7:30]-[#6:31]-[#6:32](-[#7:34](-[#6:36](-[#6:57](=[#8:58])-[#7:56]-[#6:55](-[#6:59])-[#6:53](=[#8:54])-[#7:52]-[#6:51](-[#6:60](-[#8:62])=[#8:61])-[#6:50]-[#6:48]1:[#6:49]:[#6:44]:[#6:45](-[#8:63]):[#6:46]:[#6:47]:1)-[#6:37]1:[#6:42]:[#6:41]:[#6:40](-[#8:43]):[#6:39]:[#6:38]:1)-[#6:35])=[#8:33])=[#8:29])-[#6:27])=[#8:24])-[#6:21]-[#8:22])-[#6:19])=[#8:17]>>[#6:1]-[#6:2]-[#6:3]-[#6:4]-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]-[#6:13]-[#6:14]-[#6:15]-[#6:16](-[#7:18](-[#6:20](-[#6:23](-[#7:25]-[#6:26](-[#6:28](-[#7:30]-[#6:31]-[#6:32](-[#7:34](-[#6:36]1-[#6:57](=[#8:58])-[#7:56]-[#6:55](-[#6:59])-[#6:53](=[#8:54])-[#7:52]-[#6:51](-[#6:60](-[#8:62])=[#8:61])-[#6:50]-[#6:48]2:[#6:47]:[#6:46](:[#6:45](-[#8:63]):[#6:44]:[#6:49]:2)-[#6:41]2:[#6:40](-[#8:43]):[#6:39]:[#6:38]:[#6:37]-1:[#6:42]:2)-[#6:35])=[#8:33])=[#8:29])-[#6:27])=[#8:24])-[#6:21]-[#8:22])-[#6:19])=[#8:17]",
"reactions": [
{
"substrate": "CCCCCCCCCCCCCCCC(=O)N(C)C(CO)C(=O)NC(C)C(=O)NCC(=O)N(C)C(C(=O)NC(C)C(=O)NC(Cc1ccc(O)cc1)C(=O)O)c1ccc(O)cc1",
"products": [
"CCCCCCCCCCCCCCCC(=O)N(C)C(CO)C(=O)NC(C)C(=O)NCC(=O)N(C)C1C(=O)NC(C)C(=O)NC(C(=O)O)Cc2ccc(O)c(c2)-c2cc1ccc2O"
],
"isIntermediate": true,
"description": "AryC enzymatic cross-coupling establishes the biaryl bond formation without the requirement of attaching precursor peptide substrates to PCP- or PCP-X interaction partners."
}
],
"evidence": {
"evidenceCode": [
"Inference from genomic data and chemical structure",
"In vitro assay"
],
"references": [
"doi:10.1021/ja2040877",
"doi:10.1002/chem.202103389"
]
}
}
]
}
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