Single Cell Methylomes Identify Neuronal Subtypes and Regulatory Elements in Mammalian Cortex

Science 357, 600 (2017)

More information at the project website: http://brainome.org

Chongyuan Luo^1,2,†, Christopher L. Keown^3,†, Laurie Kurihara⁴, Jingtian Zhou^1,5, Yupeng He^1,5, Junhao Li³, Rosa Castanon¹, Jacinta Lucero⁶, Joseph R. Nery¹, Justin Sandoval¹, Brian Bui⁶, Terrence J. Sejnowski^2,6, Timothy Harkins⁴, Eran A. Mukamel^3,*, M. Margarita Behrens^6,*, Joseph R. Ecker^1,2,*

1. Genomic Analysis Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, United States.
2. Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, United States.
3. Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92037, United States.
4. Swift Biosciences Inc, 58 Parkland Plaza, Ste. 100, Ann Arbor, MI 48103, United States.
5. Bioinformatics Program, University of California, San Diego, La Jolla, CA 92093, United States.
6. Computational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States.

Contact: emukamel [at] ucsd [dot] edu; mbehrens [at] salk [dot] edu; ecker [at] salk [dot] edu

Data browsers:

• User guide for the AnnoJ genome browser
• Mouse genome browser (AnnoJ)
• Human genome browser (AnnoJ)
• Mouse and Human tSNE browser

Data download

• GEO GSE97179

snmcseq

Tools for computational analysis of single nuclei methylC-Seq data, as described in Luo, Keown et al. (2017)

Contact: Chris Keown (ckeown @ ucsd.edu), Eran Mukamel (emukamel @ ucsd.edu)

Mukamel lab: http://brainome.ucsd.edu

See also: Methylpy https://github.com/yupenghe/methylpy

Mukamel lab: http://brainome.ucsd.edu