R-based comparison of HISAT2 vs Bowtie2 alignment performance across RNA-Seq and WGS applications using chr21 reference and platform-representative simulated data; includes MAPQ-based SAM quality assessment.
bioinformatics rna-seq genomics ngs r-language hisat2 sequence-alignment whole-genome-sequencing read-mapping bowtie2 sam-format mapq
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Updated
Jun 20, 2026 - R